Drug-induced dermatomyositis after lacosamide: A case report.

Here we describe a caseof a woman who had DM after treatment withlacosamide. To our knowledge, drug-induced DMfrom lacosamide has not been reported previously

Investigating the effect of target of rapamycin kinase inhibition on the Chlamydomonas reinhardtii phosphoproteome: from known homologs to new targets

Recuperado de: https://www.biorxiv.org/content/10.1101/310102v1Target of rapamycin (TOR) kinase is a conserved regulator of cell growth whose activity is modulated in response to nutrients, energy and stress. Key proteins involved in the pathway are conserved in the model photosynthetic microalga Chlamydomonas reinhardtii, but the substrates of TOR kinase and downstream signaling network have not been elucidated. Our study provides a new resource for investigating the phosphorylation networks governed by the TOR kinase pathway in Chlamydomonas. We used quantitative phosphoproteomics to investigate the effects of inhibiting Chlamydomonas TOR kinase on dynamic protein phosphorylation. Wild-type and AZD-insensitive Chlamydomonas strains were treated with TOR-specific chemical inhibitors (rapamycin, AZD8055 and Torin1), after which differentially affected phosphosites were identified. Our quantitative phosphoproteomic dataset comprised 2547 unique phosphosites from 1432 different proteins. Inhibition of TOR kinase caused significant quantitative changes in phosphorylation at 258 phosphosites, from 219 unique phosphopeptides. Our results include Chlamydomonas homologs of TOR signaling-related proteins, including a site on RPS6 with a decrease in phosphorylation. Additionally, phosphosites on proteins involved in translation and carotenoid biosynthesis were identified. Follow-up experiments guided by these phosphoproteomic findings in lycopene beta/epsilon cyclase showed that carotenoid levels are affected by TORC1 inhibition and carotenoid production is under TOR control in algae.National Science Foundation CAREER MCB-155252

A Three Dimensional Lattice of Ion Traps

We propose an ion trap configuration such that individual traps can be stacked together in a three dimensional simple cubic arrangement. The isolated trap as well as the extended array of ion traps are characterized for different locations in the lattice, illustrating the robustness of the lattice of traps concept. Ease in the addressing of ions at each lattice site, individually or simultaneously, makes this system naturally suitable for a number of experiments. Application of this trap to precision spectroscopy, quantum information processing and the study of few particle interacting system are discussed.Comment: 4 pages, 4 Figures. Fig 1 appears as a composite of 1a, 1b, 1c and 1d. Fig 2 appears as a composite of 2a, 2b and 2

Terahertz frequency standard based on three-photon coherent population trapping

A scheme for a THz frequency standard based on three-photon coherent population trapping in stored ions is proposed. Assuming the propagation directions of the three lasers obey the phase matching condition, we show that stability of few 10$^{-14}$ at one second can be reached with a precision limited by power broadening to $10^{-11}$ in the less favorable case. The referenced THz signal can be propagated over long distances, the useful information being carried by the relative frequency of the three optical photons.Comment: article soumis a PRL le 21 mars 2007, accepte le 10 mai, version 2 (24/05/2007

Post-piledriver concept letter

This is the concept for a series of post-shot investigations at the Piledriver site, Area 15, Nevada Test Site (NTS), to gain information on: Chimney geometry and associated wall rock conditions resulting from a deeply buried (1500-ft) nuclear explosion in granite; The characteristics and distribution of rubble and radioactivity in the chimney; and Data pertinent to in-situ leaching. These categories define the three phases of this proposal in chronological order. The technical programs under Phases II and III will depend on the results of Phase 1. Presently, it is not known whether or not there has been a collapse of the Piledriver cavity. If collapse occurred, the predicted dimensions of the chimney, based on Hardhat experience, are expected to be 250 ft in diameter and 560 ft high. For the purpose of this discussion, it is assumed this condition exists

Experimental evidence to support the double head wave method of generating a rare faction first motion

An earlier report suggested a double headwave method of generating a rarefaction first motion. In this method a geologic situation is selected so that energy that has been critically refracted once above the shot and once below shot arrives first. Since the theory of headwaves gives in the usual stationary phase approximation a ninety degree phase shift for each critical refraction, energy that has been critically refracted twice produces a 180 degree phase shift. Oil well data was presented to show that the necessary geologic situation exists in nature. A question has come up regarding the propagation of long wave lengths (16,000 ft) in the thin bed (3000 ft.) above the shot in the geologic situation cited in the earlier report. At the tine of writing of the report it was realized that the thickness of the bed should be considered in propagating the 3 to 5 wavelengths along the bed. The theoretical problem of propagation in high speed elastic bed has not been solved. The best information available at this time indicates that it might indeed be possible to go out into reef country and experimentally find a location suitable to generate a rarefaction first motion by the double head wave method. As in the earlier report this scheme is offered only as a second method that could fool a set of rules regarding first notions

On reducing the amplitude of surface waves by source arrays

The Geneva conference of experts stated that surface waves help define the nature of a seismic perturbation. A `phase equalization` method has been proposed by several seismologists to determine the polarity of the source using crustal surface waves. In this report a horizontal source array is designed which will reduce the amplitude of the crustal surface waves by a factor of five. Experimental data from Geophysical Prospecting is cited to support the effectiveness of such arrays. It is thought that phase shifts will accompany this amplitude reduction. It is concluded that these amplitude and phase changes will make the phase equalization method unreliable. The significance of the report is that the Geneva negotiations must take into account the possibility of horizontal as well as vertical arrays

Penning traps as a versatile tool for precise experiments in fundamental physics

This review article describes the trapping of charged particles. The main principles of electromagnetic confinement of various species from elementary particles to heavy atoms are briefly described. The preparation and manipulation with trapped single particles, as well as methods of frequency measurements, providing unprecedented precision, are discussed. Unique applications of Penning traps in fundamental physics are presented. Ultra-precise trap-measurements of masses and magnetic moments of elementary particles (electrons, positrons, protons and antiprotons) confirm CPT-conservation, and allow accurate determination of the fine-structure constant alpha and other fundamental constants. This together with the information on the unitarity of the quark-mixing matrix, derived from the trap-measurements of atomic masses, serves for assessment of the Standard Model of the physics world. Direct mass measurements of nuclides targeted to some advanced problems of astrophysics and nuclear physics are also presented

Self-energy correction to the bound-electron g factor in H-like ions

The one-loop self-energy correction to the 1s electron g factor is evaluated to all orders in Z\alpha with an accuracy, which is essentially better than that of previous calculations of this correction. As a result, the uncertainty of the theoretical prediction for the bound-electron g factor in H-like carbon is reduced by a factor of 3. This improves the total accuracy of the recent electron-mass determination [Beier et al. Phys. Rev. Lett. 88, 011603 (2002)]. The new value of the electron mass is found to be m_e = 0.000 548 579 909 3(3) u

Collective motional resonances and instabilities of an electron cloud stored in a Penning trap

We have experimentally investigated the behavior of an electron cloud confined in a Penning trap at weak superimposed magnetic fields. Exciting the motional frequencies of the electrons by an external drive field we found the axial mode split into two components which were identified as center-of-mass and individual electron oscillations. When the trapping potential was varied, rapid electron loss appeared at numerous values of the applied voltage. They are determined by the relation n z ω z + n m ω m =ω c . ω z ,ω m ,ω c are the axial, magnetron, and cyclotron frequency of the trapped electrons, respectively. The reason for this loss is attributed to higher order contributions to the ideal quadrupole trapping potential